Studien zu chin. Arzneimittel
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Oct;27(10):874-8.
[Clinical study on treatment of advanced non-small-cell lung cancer with Chinese herbal medicine in different stages combined with chemotherapy]
Department of Oncology, Longhua Hospital affiliated to Shanghai TCM University, Shanghai. wellbeingzz@sina.com
OBJECTIVE: To observe the effect of staged Chinese herbal medicinal therapy combined with chemotherapy in treating patients with non-small-cell lung cancer (NSCLC) of stage III or IV. METHODS: Adopting prospective randomized controlled multi-centered method, the 116 patients enrolled were assigned to the treated group (n = 60) and the control group (n = 56). The control group was treated by chemotherapy alone, while the treated group treated by chemotherapy combined with Chinese herbal medicine, i.e. Kangliu Zengxiao Decoction (KLZX) was administered in the chemotherapy stage, followed with Feiyanning Decoction (FYN) in the stage after ending the chemotherapy. The survival time, Karnofsky score, main clinical symptoms and adverse reactions, etc. were observed. RESULTS: The median survival time was 15.57 months in the treated group, which was higher than that in the control group (11.17 months, P< 0.01). The improvements in tumor related symptoms such as fatigue, dyspnea, etc. in the treated group were better than those in the control group (P <0.05). In addition, adverse reactions such as leucopenia, digestive reaction (such as nausea and vomiting) in the treated group were less than those in the control group (P <0.05). CONCLUSION: Chinese herbal medicine combined with chemotherapy shows favorable effect in improving quality of life and prolonging survival time on
Int J Neurosci. 2009;119(2):255-62.
Pien Tze Huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells.
Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University Guangzhou, Guangdong, China.
Pien Tze Huang is a popular Chinese medicine for liver diseases. In the investigations of possible effects of Pien Tze Huang on the central nervous system, we first studied the in vitro anti-cancer activity of Pien Tze Huang on neuroblastoma cells (SH-SY5Y) as compared with normal fibroblasts (NIH-3T3). Results showed that Pien Tze Huang significantly decreased (p < .05) cell survival of SH-SY5Y as compared to NIH-3T3. Furthermore, the decreases in cell survival of SH-SY5Y were significantly and linearly dose-dependent (p < .05) from 400 to 1,000 microg/ml. This supports further in vivo and animal studies for anti-cancer effect, neuroprotection, and their mechanisms.
J Ethnopharmacol. 2008 Dec 11. [Epub ahead of print]
Treatment of perennial allergic rhinitis using Shi-Bi-Lin, a Chinese herbal formula.
Zhao Y, Woo KS, Ma KH, van Hansselt CA, Wong KC, Cheng KF, Lam CW, Leung PC.
Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, SAR; Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan University, PR China.
AIM OF THE STUDY: Shi-Bi-Lin (SBL) is modified from the classic formula Cang-Er-Zi-San which has been used to treat chronic rhinitis, paranasal sinusitis and allergic rhinitis by herbal practitioners. The present study aimed at patients with moderate to severe perennial allergic rhinitis. SBL which has been shown effective in treating a guinea-pig model of allergic rhinitis, was evaluated for its efficacy and safety. MATERIALS AND METHODS: 126 allergic rhinitis patients were recruited in a double-blind randomized control trial. Half of the patients received SBL capsules and the others half received placebo for 4 weeks. Symptoms scores, physician's evaluation, nose examination, quality of life, adverse effects, serum cytokines were evaluated before and after treatment. RESULTS: SBL was found to be safe and effective in relieving some symptoms of perennial allergic rhinitis, improving the nose condition, and enhancing some domains of quality of life when compare to placebo, (p<0.05). In the 2 weeks follow up after treatment completion, the SBL enjoyed a prolongation of symptom control (p=0.05). CONCLUSION: SBL relieved symptoms of nose blockage among patients with perennial allergic rhinitis, and some aspects of the quality of life were also improved. The improvement was sustained for at least 2 weeks after treatment. No serious adverse events were encountered.
J Altern Complement Med. 2008 Oct;14(8):1043-8.
The effectiveness of combined Chinese herbal medicine and acupuncture in the treatment of atopic dermatitis.
Salameh F, Perla D, Solomon M, Gamus D, Barzilai A, Greenberger S, Trau H.
Department of Dermatology, The Chaim Sheba Medical Center, Tel Hashomer, The Sackler School of Medicine, Tel Aviv University, Israel. faressalameh@hotmail.com
BACKGROUND: Patients with atopic dermatitis increasingly use complementary medicine. Objective: The objective of this study was to assess the effectiveness of the combination of Chinese herbal medicine and acupuncture for the treatment of atopic dermatitis. METHODS: Twenty (20) patients between the ages of 13 and 48 who had mild-to-severe atopic dermatitis were given a combined treatment of acupuncture and Chinese herbal medicine and were followed prospectively. The patients received acupuncture treatment twice a week and the Chinese herbal formula 3 times daily for a total of 12 weeks. Assessments were performed before treatment, and at weeks 3, 6, 9, and 12 of treatment. The primary outcomes were defined as the changes in the Eczema Area and Severity Index (EASI), Dermatology Life Quality Index (DLQI), and patient assessment of itch measured on a visual analogue scale (VAS). RESULTS: After 12 weeks of treatment, an improvement in EASI was noted in 100% of patients, when compared with the baseline. The mean EASI fell from 4.99 to 1.81; the median percentage of decrease was 63.5%. Moreover, 78.8% of patients experienced a reduction in DLQI and VAS, as compared with the baseline. The mean DLQI decreased from 12.5 to 7.6 at the end of treatment, with 39.1% improvement. Mean VAS decreased from 6.8 to 3.7, with 44.7% improvement. No adverse effects were observed. CONCLUSIONS: The results of this study suggest that the combination of acupuncture and Chinese herbal medicine have a beneficial effect on patients with atopic dermatitis and may offer better results than Chinese herbal medicine alone.
Evid Based Complement Alternat Med. 2008 Sep 27.
A Chinese Herbal Preparation Containing Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum Reduces Circulating Adhesion Molecules.
O'Brien KA, Ling S, Abbas E, Dai A, Zhang J, Wang WC, Bensoussan A, Luo R, Guo ZX, Komesaroff PA.
Faculty of Health, Engineering & Science, Victoria University, PO Box 14428, Melbourne, Victoria 8001, Australia. kylie.obrien@vu.edu.au.
Circulating adhesion molecules (CAMs), surface proteins expressed in the vascular endothelium, have emerged as risk factors for cardiovascular disease (CVD). CAMs are involved in intercellular communication that are believed to play a role in atherosclerosis. A Chinese medicine, the 'Dantonic Pill' (DP) (also known as the 'Cardiotonic Pill'), containing three Chinese herbal material medica, Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum, has been used in China for the prevention and management of CVD. Previous laboratory and animal studies have suggested that this preparation reduces both atherogenesis and adhesion molecule expression. A parallel double blind randomized placebo-controlled study was conducted to assess the effects of the DP on three species of CAM [intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 and endothelial cell selectin (E-selectin)] in participants with mild-moderate hypercholesterolemia. Secondary endpoints included biochemical and hematological variables and clinical effects. Forty participants were randomized to either treatment or control for 12 weeks. Treatment with DP was associated with a statistically significant decrease in ICAM-1 (9% decrease, P = 0.03) and E-Selectin (15% decrease, P = 0.004). There was no significant change in renal function tests, liver function tests, glucose, lipids or C-reactive protein levels and clinical adverse effects did not differ between the active and the control groups. There were no relevant changes in participants receiving placebo. These results suggest that this herbal medicine may contribute to the development of a novel approach to cardiovascular risk reduction.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jul;28(7):591-3.
[Effect of Chinese herbal medicine in the natural cycle of frozen embryo transfer]
[Article in Chinese]
Center of Medical Reproduction, Maternity and Child Health Care Hospital of Guangdong Province, Guangzhou. wujingzhi999@hotmail.com
OBJECTIVE: To study the effect of Chinese herbal medicine on the clinical pregnancy rate and implantation rate of frozen embryo transfer (FET) in a natural cycle. METHODS: Women with frozen embryos planned to receive FET and had spontaneous ovulation in a natural cycle were chosen for observation. They were assigned to the treated group and the control group, both were treated with conventional medicine in the very month of FET, but to the treated group, Chinese herbal medicine was given additionally. The clinical pregnant rate, implantation rate, endometrial thickness during transferring, as well as the levels of estrogen and progesterone 2 weeks after transfer in the two groups were observed and compared. RESULTS: The clinical pregnancy rate and implantation rate in the treated group were significant higher than those in the control group, 47.37% (36/76 cases) vs 32.14% (54/168 cases) and 22.38% (47/210 embryos) vs 16.09% (74/460 embryos), respectively (all P <0.05). Difference between the two groups in endometrial thickness, levels of estrogen and progesterone showed no statistical significance (P > 0.05). CONCLUSION: Chinese herbal medicine could enhance the clinical pregnancy rate and implantation rate in the natural cycle of FET to certain extent.